Recent advances in sonodynamic immunotherapy

J Cancer Res Clin Oncol. 2023 Apr;149(4):1645-1656. doi: 10.1007/s00432-022-04190-z. Epub 2022 Jul 13.

Abstract

Tumor immunotherapy has become an important means of tumor therapy by enhancing the immune response and triggering the activation of immune cells. However, currently, only a small number of patients respond to immunotherapy alone, and patients may experience immune-related adverse events (irAEs) during the course of treatment. Sonodynamic therapy (SDT) can produce cytotoxic substances to tumor tissue, induce apoptosis and enhance immunity. SDT combined with immunotherapy is considered a promising strategy for cancer treatment. In this mini review, we summarize the role of SDT in immunotherapy in recent years, including the application of SDT-triggered immunotherapy and the combination of SDT and immunotherapy.

Keywords: Immune; Immunotherapy; Sonodynamic therapy; Ultrasound.

Publication types

  • Review

MeSH terms

  • Apoptosis
  • Cell Line, Tumor
  • Combined Modality Therapy
  • Humans
  • Immunotherapy / adverse effects
  • Neoplasms* / therapy
  • Reactive Oxygen Species
  • Ultrasonic Therapy*

Substances

  • Reactive Oxygen Species