Three unusual hybrid sorbicillinoids with anti-inflammatory activities from the deep-sea derived fungus Penicillium sp. SCSIO06868

Xiaoyan Pang; Pei Wang; Shengrong Liao; Xuefeng Zhou; Xiuping Lin; Bin Yang; Xinpeng Tian; Junfeng Wang; Yonghong Liu

doi:10.1016/j.phytochem.2022.113311

Three unusual hybrid sorbicillinoids with anti-inflammatory activities from the deep-sea derived fungus Penicillium sp. SCSIO06868

Phytochemistry. 2022 Oct:202:113311. doi: 10.1016/j.phytochem.2022.113311. Epub 2022 Jul 10.

Authors

Xiaoyan Pang¹, Pei Wang², Shengrong Liao¹, Xuefeng Zhou¹, Xiuping Lin¹, Bin Yang¹, Xinpeng Tian¹, Junfeng Wang³, Yonghong Liu⁴

Affiliations

¹ CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China.
² Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China.
³ CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China. Electronic address: wangjunfeng@scsio.ac.cn.
⁴ CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China. Electronic address: yonghongliu@scsio.ac.cn.

PMID: 35830939
DOI: 10.1016/j.phytochem.2022.113311

Abstract

Under the guidance of MS/MS based molecular networking, bisorbicillchaetones A-C, three undescribed hybrid sorbicillinoids, were isolated from cultures of the deep-sea derived fungus Penicillium sp. SCSIO06868. The planar structures and absolute configurations of these compounds were determined by extensive spectroscopic analyses. Bisorbicillchaetones are the first examples of hybrid sorbicillinoids containing a coniochaetone unit. Bisorbicillchaetones A and B exhibited moderate inhibitory effect on NO production in LPS activated RAW264.7 cells with the IC₅₀ values of 80.3 ± 3.6 μM and 38.4 ± 3.3 μM, respectively, without cytotoxicity observed.

Keywords: Anti-inflammatory activities; Aspergillaceae; Deep-sea derived fungus; Molecular networking; Penicillium sp. SCSIO06868; Sorbicillinoids.

MeSH terms

Animals
Anti-Inflammatory Agents / pharmacology
Fungi
Mice
Molecular Structure
Penicillium* / chemistry
RAW 264.7 Cells
Tandem Mass Spectrometry

Substances

Anti-Inflammatory Agents