Of mice, men, women, and cancer

Alice L Mueller; Sabra L Klein

doi:10.1016/j.immuni.2022.06.009

Of mice, men, women, and cancer

Immunity. 2022 Jul 12;55(7):1150-1152. doi: 10.1016/j.immuni.2022.06.009.

Authors

Alice L Mueller¹, Sabra L Klein²

Affiliations

¹ W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. Electronic address: alandfa1@jhu.edu.
² W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. Electronic address: sklein2@jhu.edu.

PMID: 35830823
DOI: 10.1016/j.immuni.2022.06.009

Abstract

The prevalence and severity of cancers in non-reproductive tissues are greater in males than females, but the sex-specific factors contributing to this remain ill described. In this issue of Immunity, Yang et al. (2022) uncover a mechanism of androgen signaling leading to an exhausted, terminally differentiated CD8⁺ T cell phenotype in male mice.

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MeSH terms

Animals
CD8-Positive T-Lymphocytes*
Cell Differentiation
Female
Humans
Male
Mice
Neoplasms*