Imaging-guided/improved diseases management for immune-strategies and beyond

Tian Zhang; Shuai Guo; Fangzhou Li; Xinmiao Lan; Yaru Jia; Jinchao Zhang; Yuanyu Huang; Xing-Jie Liang

doi:10.1016/j.addr.2022.114446

Imaging-guided/improved diseases management for immune-strategies and beyond

Adv Drug Deliv Rev. 2022 Sep:188:114446. doi: 10.1016/j.addr.2022.114446. Epub 2022 Jul 9.

Authors

Tian Zhang¹, Shuai Guo¹, Fangzhou Li², Xinmiao Lan³, Yaru Jia⁴, Jinchao Zhang⁴, Yuanyu Huang⁵, Xing-Jie Liang⁶

Affiliations

¹ School of Life Science Advanced Research Institute of Multidisciplinary Science School of Medical Technology (Institute of Engineering Medicine) Key Laboratory of Molecular Medicine and Biotherapy Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Beijing Institute of Technology, Beijing 100081, China.
² Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China. Electronic address: lifz2020@nanoctr.cn.
³ School of Pharmaceutical Sciences, Capital Medical University, Beijing, China.
⁴ College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002, China.
⁵ School of Life Science Advanced Research Institute of Multidisciplinary Science School of Medical Technology (Institute of Engineering Medicine) Key Laboratory of Molecular Medicine and Biotherapy Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Beijing Institute of Technology, Beijing 100081, China. Electronic address: yyhuang@bit.edu.cn.
⁶ Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China; College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002, China; University of Chinese Academy of Sciences. Beijing 100049, China. Electronic address: liangxj@nanoctr.cn.

PMID: 35820600
DOI: 10.1016/j.addr.2022.114446

Abstract

Timely and accurate assessment and diagnosis are extremely important and beneficial for all diseases, especially for some of the major human disease, such as cancers, cardiovascular diseases, infectious diseases, and neurodegenerative diseases. Limited by the variable disease microenvironment, early imperceptible symptoms, complex immune system interactions, and delayed clinical phenotypes, disease diagnosis and treatment are difficult in most cases. Molecular imaging (MI) techniques can track therapeutic drugs and disease sites in vivo and in vitro in a non-invasive, real-time and visible strategies. Comprehensive visual imaging and quantitative analysis based on different levels can help to clarify the disease process, pathogenesis, drug pharmacokinetics, and further evaluate the therapeutic effects. This review summarizes the application of different MI techniques in the diagnosis and treatment of these major human diseases. It is hoped to shed a light on the development of related technologies and fields.

Keywords: Cancers; Cardiovascular diseases; Infectious diseases; Molecular imaging; Neurodegenerative diseases.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Molecular Imaging*