EAHP 2020 workshop proceedings, pediatric myeloid neoplasms

R J Leguit; A Orazi; N Kucine; H M Kvasnicka; U Gianelli; D A Arber; A Porwit; M Ponzoni

doi:10.1007/s00428-022-03375-8

EAHP 2020 workshop proceedings, pediatric myeloid neoplasms

Virchows Arch. 2022 Oct;481(4):621-646. doi: 10.1007/s00428-022-03375-8. Epub 2022 Jul 11.

Authors

R J Leguit¹, A Orazi², N Kucine³, H M Kvasnicka⁴, U Gianelli⁵, D A Arber⁶, A Porwit⁷, M Ponzoni⁸

Affiliations

¹ Department of Pathology, University Medical Center Utrecht, H04-312, POB 85500, 3508, GA, Utrecht, The Netherlands. R.J.Leguit-2@umcutrecht.nl.
² Department of Pathology, Texas Tech University Health Sciences Center El Paso, 4800 Alberta Avenue, El Paso, TX, 79905, USA.
³ Department of Pediatrics, Division of Hematology/Oncology, Weill Cornell Medicine, 525 E. 68th St, Payson-695, New York, NY, 10065, USA.
⁴ Institute of Pathology and Molecular Pathology, University of Witten/Herdecke, Witten, Germany.
⁵ Pathology Unit, Department of Pathophysiology and Transplantation, University of Milan and IRCCS Fondazione Ca' Granda - Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy.
⁶ Department of Pathology, University of Chicago, Chicago, IL, USA.
⁷ Faculty of Medicine, Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden.
⁸ Vita Salute San Raffaele University and Pathology and Lymphoid Malignancies Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Abstract

The first section of the bone marrow workshop of the European Association of Haematopathology (EAHP) 2020 Virtual Meeting was dedicated to pediatric myeloid neoplasms. The section covered the whole spectrum of myeloid neoplasms, including myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), myelodysplastic/myeloproliferative neoplasms (MDS/MPN), and acute myeloid leukemia (AML). The workshop cases are hereby presented, preceded by an introduction on these overall rare diseases in this age group. Very rare entities such as primary myelofibrosis, pediatric MDS with fibrosis, and MDS/MPN with JMML-like features and t(4;17)(q12;q21); FIP1L1::RARA fusion, are described in more detail.

Keywords: Acute leukemia; Bone marrow biopsy; EAHP workshop; Juvenile myelomonocytic leukemia; Myelodysplastic syndrome; Myeloproliferative neoplasm; Pediatric.

Publication types

Congress

MeSH terms

Bone Marrow / pathology
Child
Humans
Myelodysplastic Syndromes* / diagnosis
Myelodysplastic Syndromes* / genetics
Myelodysplastic Syndromes* / pathology
Myelodysplastic-Myeloproliferative Diseases*
Myeloproliferative Disorders* / diagnosis
Myeloproliferative Disorders* / genetics
Myeloproliferative Disorders* / pathology
Neoplasms* / pathology