Tetrodotoxin and analogues in two local pufferfish species from Inhaca Island - South of Mozambique: First report in the Mozambican coast

Isidro José Tamele; Ilário Timba; Pedro Reis Costa; Vitor Vasconcelos

doi:10.1016/j.toxicon.2022.06.011

Tetrodotoxin and analogues in two local pufferfish species from Inhaca Island - South of Mozambique: First report in the Mozambican coast

Toxicon. 2022 Sep:216:88-91. doi: 10.1016/j.toxicon.2022.06.011. Epub 2022 Jul 9.

Authors

Isidro José Tamele¹, Ilário Timba², Pedro Reis Costa³, Vitor Vasconcelos⁴

Affiliations

¹ CIIMAR/CIMAR-LA-Interdisciplinary Center of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Lexiões, Avenida General Norton de Matos, 4450-238, Matosinhos, Portugal; Institute of Biomedical Science Abel Salazar, University of Porto, R. Jorge de Viterbo Ferreira 228, 4050-313, Porto, Portugal; Department of Chemistry, Faculty of Sciences, Eduardo Mondlane University, Av. Julius Nyerere, n 3453, Campus Principal, Maputo, 257, Mozambique. Electronic address: isitamele@gmail.com.
² Marine Biology Station of Inhaca, Faculty of Sciences, Eduardo Mondlane University, Av. Julius Nyerere, nr 3453, Campus Principal, 257, Maputo, Mozambique. Electronic address: ilariolucast@gmail.com.
³ IPMA - Instituto Português do Mar e da Atmosfera, Rua Alfredo Magalhães Ramalho, 6, 1495-006, Lisbon, Portugal. Electronic address: prcosta@ipma.pt.
⁴ CIIMAR/CIMAR-LA-Interdisciplinary Center of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Lexiões, Avenida General Norton de Matos, 4450-238, Matosinhos, Portugal; Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4069-007, Porto, Portugal. Electronic address: vmvascon@fc.up.pt.

PMID: 35817092
DOI: 10.1016/j.toxicon.2022.06.011

Abstract

Tetrodotoxins (TTXs) were investigated in two local pufferfish species, Diodon hystrix and Arothron hispidus, from Mozambican coast. TTX and analogues 4-epiTTX, 4,9-anhydroTTX, 11-deoxyTTX, and 11-norTTX-6-(R/S)-ol were found in both species and high level of TTX was found in A. hispidus (9522.0 μg TTX kg^-1) than in D. hystrix (350.9 μg TTX kg^-1). The distribution of TTX and their analogues in A. hispidus was intestine > liver > skin ≫ muscle > gonads. This is the first report of TTXs in Mozambican coast.

Keywords: Human seafood poisoning; Indian Ocean; Marine toxins monitoring; Mozambican coast; Pufferfish; Tetrodotoxins.

MeSH terms

Animals
Liver
Mozambique
Tetraodontiformes*
Tetrodotoxin

Substances

Tetrodotoxin