Detecting and inactivating severe acute respiratory syndrome coronavirus-2 under the auspices of electrochemistry

Ghazala Ashraf; Ayesha Aziz; Rubina Naz Qaisrani; Wei Chen; Muhammad Asif

doi:10.1016/j.crchbi.2021.100001

Detecting and inactivating severe acute respiratory syndrome coronavirus-2 under the auspices of electrochemistry

Curr Res Chem Biol. 2021:1:100001. doi: 10.1016/j.crchbi.2021.100001. Epub 2021 Mar 1.

Authors

Ghazala Ashraf¹, Ayesha Aziz^{1

2}, Rubina Naz Qaisrani³, Wei Chen¹, Muhammad Asif²

Affiliations

¹ Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, 430074, PR China.
² Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan, 430205, China.
³ Institute of Chemical Sciences, Gomal University, Dera Ismail Khan, 29050, Pakistan.

Abstract

The recent epidemic of novel coronavirus (COVID-19) has turned out to be a huge public health concern owing to its fast transmission. Rapid and cost-effective detection of SARS-CoV-2 is crucial to classify diseased individuals. Serological examination based on antibody chromatography as a substitute to RT-PCR provides inadequate help owing to sophisticated personnel, false-positive results, special equipment and high cost. Biosensing techniques provide sensitive and specific detection, recognition and quantification of pathogens. Herein, after an introduction, we review potential electrochemical (EC) biosensors for COVID-19 diagnosis, emphasizing plasmonic, optical, colorimetric and aptamer-based sensors with a special focus on EC biosensors and point-of-care (POC) diagnostic methods. We have conferred the working principle of these biosensors, EC performance in terms of particular analytical figures of merit and their real-time applications in biological matrices. Lastly, we have described briefly the inactivation of SARS-CoV-2 by EC oxidation. In the end, we have concluded this review by clearing up the strengths and weaknesses of EC sensors and future directions. Advancement in research and technology would be our unsurpassed weapons in the fight against COVID-19 and preventing imminent pandemics.

Keywords: Detection; Electrochemical sensor; Electrochemistry; Nanomaterials; SARS-CoV-2.

Publication types

Review