Association Between Fat Graft Retention and Blood Flow in Localized Scleroderma Patients: A Pilot Study

Hayson Chenyu Wang; Yunzhu Li; Zhujun Li; Liquan Wang; Ziming Li; Xiao Long

doi:10.3389/fmed.2022.945691

Association Between Fat Graft Retention and Blood Flow in Localized Scleroderma Patients: A Pilot Study

Front Med (Lausanne). 2022 Jun 23:9:945691. doi: 10.3389/fmed.2022.945691. eCollection 2022.

Authors

Hayson Chenyu Wang¹, Yunzhu Li², Zhujun Li², Liquan Wang², Ziming Li², Xiao Long²

Affiliations

¹ Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Department of Plastic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Abstract

Background: Microcirculation plays a vital role in scleroderma physiopathology and the mechanism of fat survival.

Objective: This study aims to assess the blood perfusion change after fat grafting and evaluate the relationship between blood perfusion and fat graft retention in patients with localized scleroderma (LS).

Methods: A pilot study was conducted in patients with LS receiving autologous fat grafting (AFG). Fat graft retention measured by magnetic resonance imaging (MRI) analysis and blood flow perfusion measured by laser speckle contrast imaging 6 months postoperatively were noted. PUMC Localized Scleroderma Facial Aesthetic Index was used to assess the improvement of facial aesthetic impairment.

Results: The fat retention at the 6-month follow-up was 34.56 ± 11.89 percent. At the 6th month of follow-up, the relative blood perfusion at the lesion area was 115.08 ± 14.39 PU, significantly higher than 100.42 ± 10.62 PU at the pre-operation (p = 0.010). The blood perfusion at follow-up increased by an average of 1.15 ± 0.14 times before the operation. No association between the increase in the blood flow perfusions and fat graft retention was found (r = -0.082, p = 0.811).

Conclusion: Local blood perfusion in the lesion area relatively increased after AFG, but no direct relationship was found between fat retention and increased blood supply.

Keywords: autologous fat grafting; blood flow; fat retention; localized scleroderma; microcirculation.