Combination of Panax ginseng C. A. Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats

Hayder M Al-Kuraishy; Hany A Al-Hussaniy; Ali I Al-Gareeb; Walaa A Negm; Aya H El-Kadem; Gaber El-Saber Batiha; Nermeen N Welson; Gomaa Mostafa-Hedeab; Ahmed H Qasem; Carlos Adam Conte-Junior

doi:10.3389/fphar.2022.905828

Combination of Panax ginseng C. A. Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats

Front Pharmacol. 2022 Jun 22:13:905828. doi: 10.3389/fphar.2022.905828. eCollection 2022.

Authors

Affiliations

¹ Department of Clinical Pharmacology and Therapeutic, College of Medicine, Al-Mustansiriyah University, Baghdad, Iraq.
² Department of Anesthesia, Al-Nukaba University College, Baghdad, Iraq.
³ Pharmacognosy Department, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
⁴ Pharmacology and Toxicology Department, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
⁵ Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.
⁶ Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
⁷ Pharmacology Department & Health Research Unit, Medical College, Jouf University, Sakakah, Saudi Arabia.
⁸ Pharmacology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
⁹ Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
¹⁰ Center for Food Analysis (NAL), Technological Development Support Laboratory (LADETEC), Federal University of Rio de Janeiro (UFRJ), Cidade Universitária, Rio de Janeiro, Brazil.

Abstract

Doxorubicin (DOX) is an anticancer agent for treating solid and soft tissue malignancies. However, the clinical use of DOX is restricted by cumulative, dose-dependent cardiotoxicity. Therefore, the present study aimed to assess the cardioprotective effects of P. ginseng C. A. Mey, febuxostat, and their combination against DOX-induced cardiotoxicity. Thirty-five Sprague Dawley male rats were used in this study. The animals were randomly divided into five groups, with seven rats per group. The control group received normal saline, the induced group received DOX only, and the treated group received P. ginseng, febuxostat, and their combination before DOX treatment. Biomarkers of acute cardiac toxicity were assessed in each group. Results showed that treatment with the combination of febuxostat and P. ginseng before DOX led to a significant improvement in the biomarkers of acute DOX-induced cardiotoxicity. In conclusion, the combination of P. ginseng and febuxostat produced more significant cardioprotective effects against DOX-induced cardiotoxicity when compared to either P. ginseng or febuxostat when used alone. The potential mechanism of this combination was mainly mediated by the anti-inflammatory and antioxidant effects of P. ginseng and febuxostat.

Keywords: BNP; TNF-α; cardiac tropinin; doxorubicin; febuxostat; ginseng; glutathione peroxidase.