Functional Connectivity Dynamics Altered of the Resting Brain in Subjective Cognitive Decline

Yi-Chia Wei; Yi-Chia Kung; Wen-Yi Huang; Chemin Lin; Yao-Liang Chen; Chih-Ken Chen; Yu-Chiau Shyu; Ching-Po Lin

doi:10.3389/fnagi.2022.817137

Functional Connectivity Dynamics Altered of the Resting Brain in Subjective Cognitive Decline

Front Aging Neurosci. 2022 Jun 24:14:817137. doi: 10.3389/fnagi.2022.817137. eCollection 2022.

Authors

Yi-Chia Wei^{1

2

3}, Yi-Chia Kung¹, Wen-Yi Huang^{2

3

4}, Chemin Lin^{2

4

5}, Yao-Liang Chen^{6

7}, Chih-Ken Chen^{2

4

5}, Yu-Chiau Shyu^{2

8}, Ching-Po Lin¹

Affiliations

¹ Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.
² Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung, Taiwan.
³ Department of Neurology, Chang Gung Memorial Hospital, Keelung, Taiwan.
⁴ College of Medicine, Chang Gung University, Taoyuan, Taiwan.
⁵ Department of Psychiatry, Chang Gung Memorial Hospital, Keelung, Taiwan.
⁶ Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan.
⁷ Department of Radiology, Chang Gung Memorial Hospital, Keelung, Taiwan.
⁸ Department of Nursing, Chang Gung University of Science and Technology, Taoyuan, Taiwan.

Abstract

Background: Subjective cognitive decline (SCD) appears in the preclinical stage of the Alzheimer's disease continuum. In this stage, dynamic features are more sensitive than static features to reflect early subtle changes in functional brain connectivity. Therefore, we studied local and extended dynamic connectivity of the resting brain of people with SCD to determine their intrinsic brain changes.

Methods: We enrolled cognitively normal older adults from the communities and divided them into SCD and normal control (NC) groups. We used mean dynamic amplitude of low-frequency fluctuation (mdALFF) to evaluate region of interest (ROI)-wise local dynamic connectivity of resting-state functional MRI. The dynamic functional connectivity (dFC) between ROIs was tested by whole-brain-based statistics.

Results: When comparing SCD (N = 40) with NC (N = 45), mdALFF_mean decreased at right inferior parietal lobule (IPL) of the frontoparietal network (FPN). Still, it increased at the right middle temporal gyrus (MTG) of the ventral attention network (VAN) and right calcarine of the visual network (VIS). Also, the mdALFF_var (variance) increased at the left superior temporal gyrus of AUD, right MTG of VAN, right globus pallidum of the cingulo-opercular network (CON), and right lingual gyrus of VIS. Furthermore, mdALFF_mean at right IPL of FPN are correlated negatively with subjective complaints and positively with objective cognitive performance. In the dFC seeded from the ROIs with local mdALFF group differences, SCD showed a generally lower dFC_mean and higher dFC_var (variance) to other regions of the brain. These weakened and unstable functional connectivity appeared among FPN, CON, the default mode network, and the salience network, the large-scale networks of the triple network model for organizing neural resource allocations.

Conclusion: The local dynamic connectivity of SCD decreased in brain regions of cognitive executive control. Meanwhile, compensatory visual efforts and bottom-up attention rose. Mixed decrease and compensatory increase of dynamics of intrinsic brain activity suggest the transitional nature of SCD. The FPN local dynamics balance subjective and objective cognition and maintain cognitive preservation in preclinical dementia. Aberrant triple network model features the dFC alternations of SCD. Finally, the right lateralization phenomenon emerged early in the dementia continuum and affected local dynamic connectivity.

Keywords: dynamic functional connectivity; dynamics; mdALFF; preclinical dementia; resting state functional MRI; subjective cognitive decline (SCD).