Intra-Host Diversity of Dengue Virus in Mosquito Vectors

Amanda Makha Bifani; Tanamas Siriphanitchakorn; Milly M Choy

doi:10.3389/fcimb.2022.888804

Intra-Host Diversity of Dengue Virus in Mosquito Vectors

Front Cell Infect Microbiol. 2022 Jun 22:12:888804. doi: 10.3389/fcimb.2022.888804. eCollection 2022.

Authors

Amanda Makha Bifani¹, Tanamas Siriphanitchakorn¹, Milly M Choy¹

Affiliation

¹ Programme in Emerging Infectious Diseases, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.

Abstract

Dengue virus (DENV) is the most common arbovirus, causing a significant burden on both the economy and global healthcare systems. The virus is transmitted by Aedes species of mosquitoes as a swarm of closely related virus genomes, collectively referred to as a quasispecies. The level of genomic diversity within this quasispecies varies as DENV moves through various ecological niches within its transmission cycle. Here, the factors that influence the level of DENV quasispecies diversity during the course of infection in the mosquito vectors are reviewed.

Keywords: Aedes; DENV; dengue; genome diversity; quasispecies.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aedes*
Animals
Arboviruses*
Dengue Virus* / genetics
Genome, Viral
Mosquito Vectors