Programmable design and self assembly of peptide conjugated AIEgens for biomedical applications

Ni-Yuan Zhang; Xing-Jie Hu; Hong-Wei An; Jian-Xiao Liang; Hao Wang

doi:10.1016/j.biomaterials.2022.121655

Programmable design and self assembly of peptide conjugated AIEgens for biomedical applications

Biomaterials. 2022 Aug:287:121655. doi: 10.1016/j.biomaterials.2022.121655. Epub 2022 Jun 27.

Authors

Ni-Yuan Zhang¹, Xing-Jie Hu², Hong-Wei An³, Jian-Xiao Liang¹, Hao Wang⁴

Affiliations

¹ CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, 100190, Beijing, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, PR China.
² CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, 100190, Beijing, China; Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, 450052, China.
³ CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, 100190, Beijing, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, PR China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, PR China.
⁴ CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, 100190, Beijing, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, PR China. Electronic address: wanghao@nanoctr.cn.

PMID: 35810541
DOI: 10.1016/j.biomaterials.2022.121655

Abstract

Aggregation-induced emission luminogens (AIEgens) possess enhanced fluorescence in highly aggregated states, thus enabling AIEgens as a promising module for highly emissive fluorescence biomaterials. So far, AIEgens-based nanomaterials and their hybrids have been reported for biomedical applications. Benefiting from the intrinsic biocompatibility and biofunction-editing properties of peptides, peptide-AIEgens hybrid biomaterials reveal unlimited possibilities including target capacity, specificity, stimuli-responsiveness, self-assembly, controllable structural transformation, etc.. In the last two decades, peptide-AIEgens hybrid nanomaterials with a unique design concept in aggregated states have achieved various biomedical applications such as biosensing, bioimaging, imaging-guided surgery, drug delivery and therapy. More recently, programmable design of peptide-AIEgens for in situ self-assembly provides a unique strategy for constructing intelligent entities with defined biological functions. In this review, we summarize the basic design principle of programmable peptide-AIEgens, structure-effect relationship and their unusual biomedical effects. Finally, an outlook and perspective toward future challenges and developments of peptide-AIEgens nanomaterials are concluded.

Keywords: AIEgens; Bioimaging; Biosensing; Peptide; Programmable; Self-assembly.