Research on the progress of Traditional Chinese medicine components and preparations on histone deacetylase inhibitors - Like effects in the course of disease treatment

Yuxin Wei; Yuyan Guo; Shaowa Lv

doi:10.1016/j.jep.2022.115521

Research on the progress of Traditional Chinese medicine components and preparations on histone deacetylase inhibitors - Like effects in the course of disease treatment

J Ethnopharmacol. 2022 Oct 5:296:115521. doi: 10.1016/j.jep.2022.115521. Epub 2022 Jul 6.

Authors

Yuxin Wei¹, Yuyan Guo¹, Shaowa Lv²

Affiliations

¹ Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, China.
² Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, China. Electronic address: lswa5599@hotmail.com.

PMID: 35809757
DOI: 10.1016/j.jep.2022.115521

Abstract

Ethnopharmacological relevance: During the treatment of diseases, histone deacetylases (HDAC) may have side effects such as strong immune inhibition and drug resistance, which may lead to damage of heart, liver and kidney. Traditional Chinese medicine (TCM) is a valuable and unique resource in China, which has good efficacy and safety. At present, it has been found that Chinese herbal compounds and active ingredients can effectively inhibit the expression of HDAC. Moreover, pharmacological studies have shown that these TCMs have shown therapeutic effects in the treatment of cancer, cardiovascular and cerebrovascular diseases, orthopedic diseases and skin diseases.

Aim of the review: This article reviews the mechanism of action of HDAC, and introduces the epigenetic correlation between TCM and HDAC. We expounded the histone deacetylase inhibitor (HDACi)-like inhibitory effect and clinical application of natural drugs, and summarized the research progress of TCM on HDAC in recent years.

Materials and methods: We collected relevant information published before March 2022 by searching the literature in various online databases such as PubMed, CNKI, Wanfang Database, Elsevier, Web of Science and China Biomedical Database. Search terms include "HDAC" or "HDACi", as well as "herb" or "herbal ingredient".

Results: A large number of studies have proved that many TCMs and their chemical components have the effect of inhibiting HDAC activity, which is highly selective, acts on different HDAC subtypes, and plays a certain therapeutic effect in cancer, cardiovascular and cerebrovascular diseases, orthopedic diseases, skin diseases and other diseases by inhibiting the process of HDAC.

Discussion and conclusions: The review of this paper is helpful to understand and excavate the active components of TCM, further explore the role of plant drugs with HDACi-like effect in diseases, and provide ideas for the development of new HDACi.

Keywords: Cance; Cardiovascular and cerebrovascular diseases; Dermatosis; Epigenetics; HDAC; HDACi; Herb; Orthopedic diseases.

Publication types

Review

MeSH terms

Drugs, Chinese Herbal* / chemistry
Drugs, Chinese Herbal* / pharmacology
Drugs, Chinese Herbal* / therapeutic use
Histone Deacetylase Inhibitors / adverse effects
Humans
Medicine, Chinese Traditional
Molecular Targeted Therapy
Neoplasms* / chemically induced
Neoplasms* / drug therapy

Substances

Drugs, Chinese Herbal
Histone Deacetylase Inhibitors