Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis

Shang-Yu Yang; Chi-Jung Fang; Yu-Wen Chen; Wan-Ping Chen; Li-Ya Lee; Chin-Chu Chen; Yen-You Lin; Shan-Chi Liu; Chun-Hao Tsai; Wei-Chien Huang; Yang-Chang Wu; Chih-Hsin Tang

doi:10.3390/nu14132605

Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis

Nutrients. 2022 Jun 23;14(13):2605. doi: 10.3390/nu14132605.

Authors

Shang-Yu Yang¹, Chi-Jung Fang², Yu-Wen Chen³, Wan-Ping Chen³, Li-Ya Lee³, Chin-Chu Chen^{4

5

6}, Yen-You Lin⁷, Shan-Chi Liu⁸, Chun-Hao Tsai^{9

10}, Wei-Chien Huang^{11

12}, Yang-Chang Wu^{13

14}, Chih-Hsin Tang^{7

11

15

16}

Affiliations

¹ Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan.
² Department of Orthopaedic Surgery, An Nan Hospital, China Medical University, Tainan 40447, Taiwan.
³ Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325002, Taiwan.
⁴ Institute of Food Science and Technology, National Taiwan University, Taipei 106617, Taiwan.
⁵ Department of Food Science, Nutrition and Nutraceutical Biotechnology, Shih Chien University, Taipei 104, Taiwan.
⁶ Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan 320314, Taiwan.
⁷ Department of Pharmacology, School of Medicine, China Medical University, Taichung 404333, Taiwan.
⁸ Department of Medical Education and Research, China Medical University Beigang Hospital, Yunlin 651012, Taiwan.
⁹ Department of Orthopedic Surgery, China Medical University Hospital, Taichung 404333, Taiwan.
¹⁰ Department of Sports Medicine, College of Health Care, China Medical University, Taichung 404333, Taiwan.
¹¹ Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan.
¹² Drug Development Center, China Medical University, Taichung 404333, Taiwan.
¹³ Department of Chinese Medicine, China Medical University Hospital, Taichung 404333, Taiwan.
¹⁴ Chinese Medicine Research and Development Center, China Medical University Hospital, China Medical University, Taichung 404333, Taiwan.
¹⁵ Chinese Medicine Research Center, China Medical University, Taichung 404333, Taiwan.
¹⁶ Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 41354, Taiwan.

Abstract

Osteoarthritis (OA) is an age-related disorder that affects the joints and causes functional disability. Hericium erinaceus is a large edible mushroom with several known medicinal functions. However, the therapeutic effects of H. erinaceus in OA are unknown. In this study, data from Sprague-Dawley rats with knee OA induced by anterior cruciate ligament transection (ACLT) indicated that H. erinaceus mycelium improves ACLT-induced weight-bearing asymmetry and minimizes pain. ACLT-induced increases in articular cartilage degradation and bone erosion were significantly reduced by treatment with H. erinaceus mycelium. In addition, H. erinaceus mycelium reduced the synthesis of proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in OA cartilage and synovium. H. erinaceus mycelium shows promise as a functional food in the treatment of OA.

Keywords: Hericium erinaceus; anterior cruciate ligament transection; interleukin 1 beta; mycelium; osteoarthritis; tumor necrosis factor-alpha.

MeSH terms

Animals
Cartilage, Articular*
Disease Models, Animal
Hericium
Mycelium
Osteoarthritis, Knee* / drug therapy
Osteoarthritis, Knee* / pathology
Rats
Rats, Sprague-Dawley

Supplementary concepts

Hericium erinaceus

Abstract

MeSH terms

Supplementary concepts

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