Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi's Sarcoma

Amanda de Oliveira Lopes; Pedro do Nascimento Marinho; Letícia d'Ambrosio de Souza Medeiros; Vanessa Salete de Paula

doi:10.3390/ijms23137203

Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi's Sarcoma

Int J Mol Sci. 2022 Jun 29;23(13):7203. doi: 10.3390/ijms23137203.

Authors

Amanda de Oliveira Lopes¹, Pedro do Nascimento Marinho¹, Letícia d'Ambrosio de Souza Medeiros¹, Vanessa Salete de Paula¹

Affiliation

¹ Laboratory of Molecular Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, 4365, Brasil Av., Manguinhos, Rio de Janeiro 21040-360, Brazil.

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human gammaherpesvirus 8 (HHV-8), contains oncogenes and proteins that modulate various cellular functions, including proliferation, differentiation, survival, and apoptosis, and is integral to KSHV infection and oncogenicity. In this review, we describe the most important KSHV genes [ORF 73 (LANA), ORF 72 (vCyclin), ORF 71 or ORFK13 (vFLIP), ORF 74 (vGPCR), ORF 16 (vBcl-2), ORF K2 (vIL-6), ORF K9 (vIRF 1)/ORF K10.5, ORF K10.6 (vIRF 3), ORF K1 (K1), ORF K15 (K15), and ORF 36 (vPK)] that have the potential to induce malignant phenotypic characteristics of Kaposi's sarcoma. These oncogenes can be explored in prospective studies as future therapeutic targets of Kaposi's sarcoma.

Keywords: Kaposi’s sarcoma; Kaposi’s sarcoma associated herpesvirus; oncogenes.

Publication types

Review

MeSH terms

Herpesviridae Infections*
Herpesvirus 8, Human* / genetics
Humans
Oncogenes
Prospective Studies
Sarcoma, Kaposi* / pathology

Grants and funding

This research was funded by the National Council of Scientific and Technological Development (CNPq), Coordination for the Improvement of Higher Education Personnel (CAPES), State of Rio de Janeiro Research Support Foundation (FAPERJ), and INOVA FIOCRUZ.