Magnetic Resonance Spectroscopy in Diagnosis and Follow-Up of Gliomas: State-of-the-Art

Malik Galijasevic; Ruth Steiger; Stephanie Mangesius; Julian Mangesius; Johannes Kerschbaumer; Christian Franz Freyschlag; Nadja Gruber; Tanja Janjic; Elke Ruth Gizewski; Astrid Ellen Grams

doi:10.3390/cancers14133197

Magnetic Resonance Spectroscopy in Diagnosis and Follow-Up of Gliomas: State-of-the-Art

Cancers (Basel). 2022 Jun 29;14(13):3197. doi: 10.3390/cancers14133197.

Authors

Malik Galijasevic^{1

2}, Ruth Steiger^{1

2}, Stephanie Mangesius^{1

2}, Julian Mangesius³, Johannes Kerschbaumer⁴, Christian Franz Freyschlag⁴, Nadja Gruber^{5

6}, Tanja Janjic^{1

2}, Elke Ruth Gizewski^{1

2}, Astrid Ellen Grams^{1

2}

Affiliations

¹ Department of Neuroradiology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
² Neuroimaging Research Core Facility, Medical University of Innsbruck, 6020 Innsbruck, Austria.
³ Department of Radiation Oncology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
⁴ Department of Neurosurgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
⁵ VASCage-Research Centre on Vascular Ageing and Stroke, 6020 Innsbruck, Austria.
⁶ Department of Applied Mathematics, University of Innsbruck, 6020 Innsbruck, Austria.

Abstract

Preoperative grade prediction is important in diagnostics of glioma. Even more important can be follow-up after chemotherapy and radiotherapy of high grade gliomas. In this review we provide an overview of MR-spectroscopy (MRS), technical aspects, and different clinical scenarios in the diagnostics and follow-up of gliomas in pediatric and adult populations. Furthermore, we provide a recap of the current research utility and possible future strategies regarding proton- and phosphorous-MRS in glioma research.

Keywords: glioma; imaging biomarkers; magnetic resonance spectroscopy.

Publication types

Review

Grants and funding

This research received no external funding.