PET/MR of pediatric bone tumors: what the radiologist needs to know

Jennifer Padwal; Lucia Baratto; Amit Chakraborty; Kristina Hawk; Sheri Spunt; Raffi Avedian; Heike E Daldrup-Link

doi:10.1007/s00256-022-04113-6

PET/MR of pediatric bone tumors: what the radiologist needs to know

Skeletal Radiol. 2023 Mar;52(3):315-328. doi: 10.1007/s00256-022-04113-6. Epub 2022 Jul 9.

Authors

Jennifer Padwal¹, Lucia Baratto¹, Amit Chakraborty², Kristina Hawk¹, Sheri Spunt³, Raffi Avedian⁴, Heike E Daldrup-Link^{5

6

7}

Affiliations

¹ Department of Radiology, Stanford University, Stanford, CA, 94305, USA.
² Department of Radiology, Massachusetts General Hospital, Boston, MA, 02114, USA.
³ Department of Pediatrics, Stanford University, 725 Welch Rd., Rm. 1665, Stanford, CA, 94305-5614, USA.
⁴ Department of Surgery, Division of Pediatric Orthopedic Surgery, Lucile Packard Children's Hospital, Stanford University, Stanford, CA, 94305, USA.
⁵ Department of Radiology, Stanford University, Stanford, CA, 94305, USA. H.E.Daldrup-Link@stanford.edu.
⁶ Cancer Imaging Program, Stanford Cancer Institute, Stanford, USA. H.E.Daldrup-Link@stanford.edu.
⁷ Department of Pediatrics, Stanford University, 725 Welch Rd., Rm. 1665, Stanford, CA, 94305-5614, USA. H.E.Daldrup-Link@stanford.edu.

Abstract

Integrated 2-deoxy-2-[fluorine-18]fluoro-D-glucose (¹⁸F-FDG) positron emission tomography (PET)/magnetic resonance (MR) imaging can provide "one stop" local tumor and whole-body staging in one session, thereby streamlining imaging evaluations and avoiding duplicate anesthesia in young children. ¹⁸F-FDG PET/MR scans have the benefit of lower radiation, superior soft tissue contrast, and increased patient convenience compared to ¹⁸F-FDG PET/computerized tomography scans. This article reviews the ¹⁸F-FDG PET/MR imaging technique, reporting requirements, and imaging characteristics of the most common pediatric bone tumors, including osteosarcoma, Ewing sarcoma, primary bone lymphoma, bone and bone marrow metastases, and Langerhans cell histiocytosis.

Keywords: Bone sarcoma; Magnetic resonance; PET/MR; Pediatric cancer; Positron emission tomography.

Publication types

Review

MeSH terms

Bone Neoplasms* / pathology
Child
Child, Preschool
Fluorodeoxyglucose F18*
Humans
Magnetic Resonance Imaging / methods
Magnetic Resonance Spectroscopy
Neoplasm Staging
Positron-Emission Tomography / methods
Radiologists
Radiopharmaceuticals

Substances

Fluorodeoxyglucose F18
Radiopharmaceuticals
Fluorine-18

Abstract

Publication types

MeSH terms

Substances

Grants and funding