Flaviviruses hijack the host microbiota to facilitate their transmission

Lejla Gul; Tamas Korcsmaros; Neil Hall

doi:10.1016/j.cell.2022.06.019

Flaviviruses hijack the host microbiota to facilitate their transmission

Cell. 2022 Jul 7;185(14):2395-2397. doi: 10.1016/j.cell.2022.06.019.

Authors

Lejla Gul¹, Tamas Korcsmaros², Neil Hall³

Affiliations

¹ Earlham Institute, Norwich, UK; Imperial College London, Department of Metabolism, Reproduction and Development, London, UK.
² Earlham Institute, Norwich, UK; Imperial College London, Department of Metabolism, Reproduction and Development, London, UK; Quadram Institute Bioscience, Norwich, UK.
³ Earlham Institute, Norwich, UK; Department of Biological Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia; School of Biological Sciences, University of East Anglia, Norwich, UK. Electronic address: neil.hall@earlham.ac.uk.

PMID: 35803242
DOI: 10.1016/j.cell.2022.06.019

Abstract

Flaviviruses, such as Dengue and Zika viruses, infect millions of people worldwide using mosquitos as vectors. In this issue of Cell, Zhang et al. reveal how these viruses manipulate the skin microbiome of infected hosts in a way that increases vector recruitment and viral spread. They propose vitamin A as a way to counteract the virus and decrease transmission.

Publication types

Comment

MeSH terms

Animals
Culicidae / virology
Dengue
Flavivirus Infections* / microbiology
Flavivirus Infections* / transmission
Flavivirus* / physiology
Humans
Intercellular Signaling Peptides and Proteins / metabolism*
Periodicals as Topic
Skin* / metabolism
Skin* / microbiology
Vector Borne Diseases
Zika Virus Infection

Substances

Intercellular Signaling Peptides and Proteins
resistin-like alpha protein, human

Grants and funding

BBS/E/F/000PR10355/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom