Neutrophils in the tumor microenvironment and their functional modulation by mesenchymal stromal cells

Zhiyuan Zheng; Yazhang Xu; Yufang Shi; Changshun Shao

doi:10.1016/j.cellimm.2022.104576

Neutrophils in the tumor microenvironment and their functional modulation by mesenchymal stromal cells

Cell Immunol. 2022 Sep:379:104576. doi: 10.1016/j.cellimm.2022.104576. Epub 2022 Jul 1.

Authors

Zhiyuan Zheng¹, Yazhang Xu², Yufang Shi³, Changshun Shao⁴

Affiliations

¹ The Third Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine of Soochow University, Suzhou, Jiangsu, China; Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Cancer Center, Department of Breast Surgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
² Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Cancer Center, Department of Breast Surgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
³ The Third Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine of Soochow University, Suzhou, Jiangsu, China.
⁴ The Third Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine of Soochow University, Suzhou, Jiangsu, China. Electronic address: shaoc@suda.edu.cn.

PMID: 35797932
DOI: 10.1016/j.cellimm.2022.104576

Abstract

Neutrophils are the most predominant cell population in the innate immune system. The role of neutrophils in the initiation, development and metastasis of tumor has been actively studied in recent years. In cancer, neutrophils exert both pro- and anti-cancer effects, and their phenotype and function are affected by the tumor microenvironment (TME). This review aims to summarize the role of neutrophils in tumorigenesis with emphasis on their interaction with mesenchymal stromal cells (MSCs).

Keywords: Mesenchymal stromal cells; Metastasis; Neutrophils; Tumor microenvironment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carcinogenesis
Humans
Mesenchymal Stem Cells*
Neoplasms*
Neutrophils / pathology
Tumor Microenvironment