Cryptococcus neoformans- Specific and Non- Cryptococcus neoformans-Specific Antibody Profiles in Organ Transplant Recipients With and Without Cryptococcosis

Hyunah Yoon; Antonio Nakouzi; Peter G Pappas; Vagish S Hemmige; Liise Anne Pirofski

doi:10.1093/ofid/ofac211

Cryptococcus neoformans- Specific and Non- Cryptococcus neoformans-Specific Antibody Profiles in Organ Transplant Recipients With and Without Cryptococcosis

Open Forum Infect Dis. 2022 Apr 20;9(7):ofac211. doi: 10.1093/ofid/ofac211. eCollection 2022 Jul.

Authors

Hyunah Yoon¹, Antonio Nakouzi¹, Peter G Pappas², Vagish S Hemmige¹, Liise Anne Pirofski¹

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA.
² Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Abstract

Antibody immunity has not been studied in organ transplant recipients (OTRs) with cryptococcosis. We determined serum antibody levels in OTRs: 23 cryptococcosis cases and 21 controls. Glucuronoxylomannan immunoglobulin M (IgM) and laminarin IgM were lower in cases than controls, were inversely associated with cryptococcosis status, and may hold promise as markers of cryptococcosis.

Keywords: IgM; cryptococcosis; glucuronoxylomannan; laminarin; transplant recipients.

Grants and funding

R01 AI143453/AI/NIAID NIH HHS/United States