Navigating Human Immunodeficiency Virus Screening Recommendations for People on Pre-Exposure Prophylaxis and the Need to Update Testing Algorithms

Eric A Meyerowitz; Raffaele M Bernardo; Michelle D Collins-Ogle; Jonathan M Czeresnia; Cariane M Matos; Caroline Mullis; Heather B Root; Julián A Torres-Isasiga; Helen Tsai; Barry S Zingman

doi:10.1093/ofid/ofac191

Navigating Human Immunodeficiency Virus Screening Recommendations for People on Pre-Exposure Prophylaxis and the Need to Update Testing Algorithms

Open Forum Infect Dis. 2022 Apr 15;9(7):ofac191. doi: 10.1093/ofid/ofac191. eCollection 2022 Jul.

Affiliations

¹ The AIDS Center at Montefiore, Division of Infectious Diseases, Montefiore Medical Center, Bronx, New York, USA.
² Division of Pediatric Infectious Diseases, Montefiore Medical Center, Bronx, New York, USA.

Abstract

Incident HIV infections occurring in people on PrEP may have delayed seroconversion. New CDC guidelines recommend the addition of HIV-1 viral load for screening for all on PrEP. We believe antigen/antibody screening should continue for tenofovir-based PrEP at this time.

Keywords: HIV drug resistance; HIV testing; PrEP; cabotegravir; tenofovir.