Diabesity? No worries, FKBP11 to the rescue

Cell Metab. 2022 Jul 5;34(7):942-944. doi: 10.1016/j.cmet.2022.06.006.

Abstract

Obesity-induced type 2 diabetes, or diabesity, is associated with ER stress, UPR activation, and insulin resistance through poorly understood mechanisms. Herrema et al. (2022) report that the XBP1 target FKBP11 is repressed in the obese mouse liver and that its re-expression activates a protective UPR pathway that restores insulin sensitivity.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2* / genetics
  • Diabetes Mellitus, Type 2* / metabolism
  • Insulin Resistance*
  • Liver / metabolism
  • Mice
  • Mice, Obese
  • Signal Transduction
  • Tacrolimus Binding Proteins* / genetics
  • Tacrolimus Binding Proteins* / metabolism

Substances

  • FKBP11 protein, mouse
  • Tacrolimus Binding Proteins