Determination of dexamethasone dose for cortisol suppression in adult common marmosets (Callithrix jacchus)

Kimberley A Phillips; Matthew Lopez; Adam B Salmon; Corinna N Ross; David H Abbott; John P Capitanio

doi:10.1111/jmp.12602

Determination of dexamethasone dose for cortisol suppression in adult common marmosets (Callithrix jacchus)

J Med Primatol. 2022 Dec;51(6):407-410. doi: 10.1111/jmp.12602. Epub 2022 Jul 5.

Authors

Kimberley A Phillips^{1

2}, Matthew Lopez^{1

2}, Adam B Salmon^{3

4}, Corinna N Ross², David H Abbott⁵, John P Capitanio⁶

Affiliations

¹ Department of Psychology, Trinity University, San Antonio, Texas, USA.
² Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA.
³ Department of Molecular Medicine, The Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, Texas, USA.
⁴ Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care Systems, San Antonio, Texas, USA.
⁵ Department of Obstetrics and Gynecology, Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, Wisconsin, USA.
⁶ California National Primate Research Center and Psychology Department, University of California, Davis, California, USA.

Abstract

We conducted a dose-response study of dexamethasone to investigate an optimal dexamethasone suppression test for common marmosets. Twelve marmosets received 0.1, 0.5, or 1.0 mg/kg dexamethasone. Doses of 0.5 and 1.0 mg/kg both suppressed endogenous cortisol for at least 18 h with greater individual variability in the lower 0.5 mg/kg dose.

Keywords: common marmoset; dexamethasone suppression test; glucocorticoid.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Callithrix* / physiology
Dexamethasone / pharmacology
Hydrocortisone*

Substances

Hydrocortisone
Dexamethasone

Abstract

Publication types

MeSH terms

Substances

Grants and funding