Potential intravenous immunoglobulin-induced optic disc edema

Anna K Britton; Anagha Vaze; Sam Milliken; Clare L Fraser

doi:10.1016/j.ajoc.2022.101617

Potential intravenous immunoglobulin-induced optic disc edema

Am J Ophthalmol Case Rep. 2022 Jun 16:27:101617. doi: 10.1016/j.ajoc.2022.101617. eCollection 2022 Sep.

Authors

Anna K Britton¹, Anagha Vaze², Sam Milliken^{3

4}, Clare L Fraser^{1

2}

Affiliations

¹ Sydney Eye Hospital, 8 Macquarie St, Sydney, NSW, 2000, Australia.
² Save Sight Institute, Faculty of Health and Medicine, The University of Sydney, 8 Macquarie St, Sydney, NSW, 2000, Australia.
³ St Vincent's Hospital, 390 Victoria Street, Darlinghurst, 2010, Australia.
⁴ University of New South Wales, Kensington, 2052, Australia.

Abstract

Purpose: To report a case of recurrent and bilateral optic disc edema following intravenous immunoglobulin (IVIG) administration.

Observations: A 46 year-old woman received IVIG on 3 separate occasions over 7 years for Non-Hodgkin's Lymphoma (NHL) and each time developed headaches and transient visual disturbance, and was subsequently found to have bilateral optic disc swelling. Lumbar puncture confirmed raised cerebrospinal fluid (CSF) opening pressure and there was resolution following treatment with oral acetazolamide (Diamox).

Conclusions and importance: To our knowledge there is no literature on papilledema following administration of IVIG. This case is pertinent for physicians treating patients with IVIG who develop headache, transient visual disturbance and optic disc edema.

Keywords: IVIG (Intravenous immunoglobulin); Optic disc edema; Papilledema.

Publication types

Case Reports