Nickel-catalyzed decarboxylative cross-coupling of indole-3-acetic acids with aryl bromides by convergent paired electrolysis

Chem Commun (Camb). 2022 Jul 21;58(59):8202-8205. doi: 10.1039/d2cc02641d.

Abstract

Herein, nickel-catalyzed decarboxylative cross-coupling of indole-3-acetic acids with aryl bromides by convergent paired electrolysis was developed in an undivided cell. This protocol features good functional group tolerance, and is chemical redox agent- and sacrificial electrode-free. Mechanistic studies indicated that the base was crucial for the decarboxylation step and a NiI/NiIII catalytic cycle was involved in this transformation.

MeSH terms

  • Acetates
  • Bromides*
  • Catalysis
  • Electrolysis
  • Indoles
  • Molecular Structure
  • Nickel*

Substances

  • Acetates
  • Bromides
  • Indoles
  • Nickel