Evaluation of pediatric malignancies using total-body PET/CT with half-dose [18F]-FDG

Abstract

Purpose: To explore the impact of a true half dose of [¹⁸F]-FDG on image quality in pediatric oncological patients undergoing total-body PET/CT and investigate short acquisition times with half-dose injected activity.

Methods: One hundred pediatric oncological patients who underwent total-body PET/CT using the uEXPLORER scanner after receiving a true half dose of [¹⁸F]-FDG (1.85 MBq/kg) were retrospectively enrolled. The PET images were first reconstructed using complete 600-s data and then split into 300-s, 180-s, 60-s, 40-s, and 20-s duration groups (G600 to G20). The subjective analysis was performed using 5-point Likert scales. Objective quantitative metrics included the maximum standard uptake value (SUV_max), SUV_mean, standard deviation (SD), signal-to-noise ratio (SNR), and SNR_norm of the background. The variabilities in lesion SUV_mean, SUV_max, and tumor-to-background ratio (TBR) were also calculated.

Results: The overall image quality scores in the G600, G300, G180, and G60 groups were 4.9 ± 0.2, 4.9 ± 0.3, 4.4 ± 0.5, and 3.5 ± 0.5 points, respectively. All the lesions identified in the half-dose images were localized in the G60 images, while 56% of the lesions could be clearly identified in the G20 images. With reduced acquisition time, the SUV_max and SD of the backgrounds were gradually increased, while the TBR values showed no statistically significant differences among the groups (all p > 0.1). Using the half-dose images as a reference, the variability in the lesion SUV_max gradually increased from the G180 to G20 images, while the lesion SUV_mean remained stable across all age groups. SNR_norm was highly negatively correlated with age.

Conclusion: Total-body PET/CT with a half dose of [¹⁸F]-FDG (1.85 MBq/kg, estimated whole-body effective dose: 1.76-2.57 mSv) achieved good performance in pediatric patients, with sufficient image quality and good lesion conspicuity. Sufficient image quality and lesion conspicuity could be maintained at a fast scanning time of 60 s with half-dose activity.

Keywords: Low dose; Pediatric; Total-body PET/CT; [18F]-FDG.