Undescribed specialised metabolites from the endophytic fungus Emericella sp. XL029 and their antimicrobial activities

Peng-Jie Xian; Shu-Zhi Liu; Wen-Jing Wang; Sheng-Xiang Yang; Zhang Feng; Xiao-Long Yang

doi:10.1016/j.phytochem.2022.113303

Undescribed specialised metabolites from the endophytic fungus Emericella sp. XL029 and their antimicrobial activities

Phytochemistry. 2022 Oct:202:113303. doi: 10.1016/j.phytochem.2022.113303. Epub 2022 Jul 1.

Authors

Peng-Jie Xian¹, Shu-Zhi Liu², Wen-Jing Wang², Sheng-Xiang Yang³, Zhang Feng⁴, Xiao-Long Yang⁵

Affiliations

¹ School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, China.
² The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province, School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, China.
³ Zhejiang Provincial Collaborative Innovation Center for Bamboo Resources and High-efficiency Utilization & Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass, Zhejiang A & F University, Lin'an, 311300, China.
⁴ School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, China. Electronic address: fengzh@cqu.edu.cn.
⁵ School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, China; The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province, School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, China. Electronic address: yxl19830915@163.com.

PMID: 35787351
DOI: 10.1016/j.phytochem.2022.113303

Abstract

The fungus Emericella sp. XL029 isolated from leaves of Panax notoginseng was investigated for agents with potential antibacterial and antifungal activities using a one strain-many compounds (OSMAC) strategy. Fifteen compounds, including seven undescribed structures, were obtained from this species. Their structures were confirmed by extensive spectroscopic data, single-crystal X-ray crystallography and quantum chemistry calculations. Emerlactam A exhibited better antibacterial activity against multidrug-resistant Enterococcus faecium and antifungal activity against Helminthosporium maydis, with an MIC value of 12.5 μg/mL. Quiannulatic acid displayed significant antibacterial activity against multidrug-resistant Enterococcus faecium and multidrug-resistant Enterococcus faecalis with MIC values of 1.56 μg/mL and 3.13 μg/mL, respectively. 5-alkenylresorcinol exhibited significant antifungal activity against all tested phytopathogenic fungi with MIC values ranging from 6.25 to 12.5 μg/mL.

Keywords: Antibacterial activity; Antifungal activity; Araliaceae; Emericella sp.; OSMAC strategy; Panax notoginseng; Trichocomaceae.

MeSH terms

Anti-Bacterial Agents / chemistry
Antifungal Agents / chemistry
Emericella* / chemistry
Fungi
Microbial Sensitivity Tests
Molecular Structure

Substances

Anti-Bacterial Agents
Antifungal Agents