Applications and Achievements of Single-Cell Sequencing in Gastrointestinal Cancer

Zhenliang Xie; Jincheng Li; Pu Huang; Ye Zhang; Jingkuan Yang; Kangdong Liu; Yanan Jiang

doi:10.3389/fonc.2022.905571

Applications and Achievements of Single-Cell Sequencing in Gastrointestinal Cancer

Front Oncol. 2022 Jun 16:12:905571. doi: 10.3389/fonc.2022.905571. eCollection 2022.

Authors

Zhenliang Xie¹, Jincheng Li¹, Pu Huang¹, Ye Zhang¹, Jingkuan Yang¹, Kangdong Liu^{1

2

3

4

5

6}, Yanan Jiang^{1

2

3}

Affiliations

¹ The Pathophysiology Department, School of Basic Medical Sciences, College of Medicine, Zhengzhou University, Zhengzhou, China.
² China-US (Henan) Hormel Cancer Institute, Zhengzhou, China.
³ State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou, China.
⁴ Basic Medicine Sciences Research Center, Zhengzhou University, Zhengzhou, China.
⁵ Provincial Cooperative Innovation Center for Cancer Chemoprevention, Zhengzhou University, Zhengzhou, China.
⁶ Cancer Chemoprevention International Collaboration Laboratory, Zhengzhou, China.

Abstract

Gastrointestinal cancer represents a public health concern that seriously endangers human health. The emerging single-cell sequencing (SCS) technologies are different from the large-scale sequencing technologies which provide inaccurate data. SCS is a powerful tool for deciphering the single-cell resolutions of cellular and molecular landscapes, revealing the features of single-cell genomes, transcriptomes, and epigenomes. Recently, SCS has been applied in the field of gastrointestinal cancer research for clarifying the origin and heterogeneity of gastrointestinal cancer, acquiring micro-environmental information, and improving diagnostic and treatment methods. This review outlines the applications of SCS in gastrointestinal cancer research and summarizes the most recent advances in the field.

Keywords: colon cancer; esophageal cancer; gastric cancer; gastrointestinal cancer; single-cell sequencing.

Publication types

Review