The Landscape of Exosome-Derived Non-Coding RNA in Leukemia

Bing-Jie Tang; Bao Sun; Lei Chen; Jie Xiao; Shu-Ting Huang; Ping Xu

doi:10.3389/fphar.2022.912303

The Landscape of Exosome-Derived Non-Coding RNA in Leukemia

Front Pharmacol. 2022 Jun 15:13:912303. doi: 10.3389/fphar.2022.912303. eCollection 2022.

Authors

Bing-Jie Tang^{1

2}, Bao Sun^{1

2}, Lei Chen^{1

2}, Jie Xiao^{1

2}, Shu-Ting Huang^{1

2}, Ping Xu^{1

2}

Affiliations

¹ Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.
² Institute of Clinical Pharmacy, Central South University, Changsha, China.

Abstract

Leukemia is a group of life-threatening hematological malignancies which is currently incurable and often accompanied by drug resistance or disease relapse. Understanding the pathogenesis of leukemia and finding specific therapeutic targets and biomarkers is of great importance to improve the clinical efficacy of leukemia. Exosome-derived ncRNAs have been demonstrated as critical components of intercellular communication and function as key facilitators in the leukemia biological process. This review outlines the current investigations of exosomal ncRNAs (including miRNA, circRNA, and lncRNA) as important mediators of leukemia and potential therapeutic targets and biomarkers for leukemia treatment. Moreover, we generally analyze the prospects and challenges for exosomal ncRNAs from the aspects of research and clinical application.

Keywords: biomarker; exosome; leukemia; non-coding RNA; therapeutic target; tumor development.

Publication types

Review