Autoimmune Hepatitis Triggered by COVID-19 Vaccine: The First Case From Inactivated Vaccine

Krittaya Mekritthikrai; Peera Jaru-Ampornpan; Piyawat Komolmit; Kessarin Thanapirom

doi:10.14309/crj.0000000000000811

Autoimmune Hepatitis Triggered by COVID-19 Vaccine: The First Case From Inactivated Vaccine

ACG Case Rep J. 2022 Jul 1;9(7):e00811. doi: 10.14309/crj.0000000000000811. eCollection 2022 Jul.

Authors

Krittaya Mekritthikrai¹, Peera Jaru-Ampornpan², Piyawat Komolmit^{1

3

4}, Kessarin Thanapirom^{1

3

4}

Affiliations

¹ Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
² Virology and Cell Technology Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand.
³ Center of Excellence in Liver Diseases, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
⁴ Liver Fibrosis and Cirrhosis Research Unit, Chulalongkorn University, Bangkok, Thailand.

Abstract

We report a case of a 52-year-old woman without previous underlying liver disease, presenting with progressive jaundice and diagnosed with autoimmune hepatitis after 2 doses of an inactivated coronavirus disease 2019 (CoronaVac) vaccine. All serology and histology were compatible with autoimmune hepatitis. Symptoms were improved and liver function tests were normalized after treatment with steroids and azathioprine.

Publication types

Case Reports