Viral Circular RNAs and Their Possible Roles in Virus-Host Interaction

Xing Zhang; Zi Liang; Chonglong Wang; Zeen Shen; Sufei Sun; Chengliang Gong; Xiaolong Hu

doi:10.3389/fimmu.2022.939768

Viral Circular RNAs and Their Possible Roles in Virus-Host Interaction

Front Immunol. 2022 Jun 17:13:939768. doi: 10.3389/fimmu.2022.939768. eCollection 2022.

Authors

Xing Zhang¹, Zi Liang¹, Chonglong Wang¹, Zeen Shen¹, Sufei Sun¹, Chengliang Gong^{1

2}, Xiaolong Hu^{1

2}

Affiliations

¹ School of Biology and Basic Medical Science, Soochow University, Suzhou, China.
² Institute of Agricultural Biotechnology and Ecological Research, Soochow University, Suzhou, China.

Abstract

Circular RNAs (circRNAs) as novel regulatory molecules have been recognized in diverse species, including viruses. The virus-derived circRNAs play various roles in the host biological process and the life cycle of the viruses. This review summarized the circRNAs from the DNA and RNA viruses and discussed the biogenesis of viral and host circRNAs, the potential roles of viral circRNAs, and their future perspective. This review will elaborate on new insights gained on viruses encoded circRNAs during virus infection.

Keywords: DNA viruses; RNA viruses; circRNA; host-virus interactions; viral infection.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Host Microbial Interactions* / genetics
RNA, Circular* / genetics

Substances

RNA, Circular