Very few elements in the periodic system can catalytically activate O2, such as in the context of cross-dehydrogenative couplings. The development of O2-activating catalysts is essential to enable new and sustainable reactivity concepts to emerge, because these catalysts also often feature specific activating interactions with the target substrates. In this context, the unprecedented Te(II)/Te(III) catalyzed dehydrogenative C3-C2 dimerization of indoles is described herein. The fact that O2 can be directly utilized as a terminal oxidant in this reaction, as well as the absence of any background reactivity without the redox-active Te catalyst, constitute very important milestones for the fields of cross-dehydrogenative couplings and tellurium catalysis.
© 2022 The Authors. Published by American Chemical Society.