Airspace Dimension Assessment with Nanoparticles (AiDA) in Comparison to Established Pulmonary Function Tests

Madeleine Petersson-Sjögren; Jonas Jakobsson; H Laura Aaltonen; Hanna Nicklasson; Jenny Rissler; Gunnar Engström; Per Wollmer; Jakob Löndahl

doi:10.2147/IJN.S360271

Airspace Dimension Assessment with Nanoparticles (AiDA) in Comparison to Established Pulmonary Function Tests

Int J Nanomedicine. 2022 Jun 25:17:2777-2790. doi: 10.2147/IJN.S360271. eCollection 2022.

Authors

Madeleine Petersson-Sjögren^{1

2}, Jonas Jakobsson³, H Laura Aaltonen^{4

5}, Hanna Nicklasson^{6

7}, Jenny Rissler^{1

2

8}, Gunnar Engström⁹, Per Wollmer⁶, Jakob Löndahl^{1

2}

Affiliations

¹ Division of Ergonomics and Aerosol Technology, Department of Design Sciences, Lund University, Lund, Sweden.
² NanoLund, Lund University, Lund, Sweden.
³ Division of Nuclear Physics, Department of Physics, Lund University, Lund, Sweden.
⁴ Department of Translational Medicine, Medical Imaging and Physiology, Lund University, Malmö, Sweden.
⁵ Department of Radiology, University of Washington, Seattle, WA, USA.
⁶ Department of Translational Medicine, Clinical Physiology and Nuclear Medicine, Skåne University Hospital, Malmö, Sweden.
⁷ MVIC Medicon Valley Inhalation Consortium AB, Lund, Sweden.
⁸ Division of Bioeconomy and Health, RISE Research Institutes of Sweden, Borås, Sweden.
⁹ Department of Clinical Sciences, Lund University, Malmö, Sweden.

Abstract

Background: Airspace Dimensions Assessment with nanoparticles (AiDA) is a new method for non-invasive measurement of pulmonary distal airspaces. The aim of this study was to compare AiDA measurements with other pulmonary function variables to better understand the potential of AiDA in a clinical context.

Methods: AiDA measurements and pulmonary function tests were performed in 695 subjects as part of the Swedish CArdioPulmonary bioImage Study. The measurement protocol included spirometry, measurement of diffusing capacity of carbon monoxide, oscillometry and pulmonary computed tomography. AiDA indices were compared to all other pulmonary examination measurements using multivariate statistical analysis.

Results: Our results show that AiDA measurements were significantly correlated with other pulmonary function examination indices, although covariance was low. We found that AiDA variables explained variance in the data that other lung function variables only influenced to a minor extent.

Conclusion: We conclude that the AiDA method provides information about the lung that is inaccessible with more conventional lung function techniques.

Keywords: COPD diagnostics; aerosol nanoparticles; airspace dimension assessment with nanoparticles; distal airspaces; respiratory diagnostics with nanoparticles.

MeSH terms

Carbon Monoxide
Humans
Lung* / diagnostic imaging
Nanoparticles*
Respiratory Function Tests
Tomography, X-Ray Computed

Substances

Carbon Monoxide

Grants and funding

Open access funding provided by Lund University. This work was supported by the Swedish Heart and Lung foundation (Grant No 2017-0644, Grant No 2018-0483 and Grant No 2020-0855), the Swedish Research Council for Health, Working Life and Welfare (Grant No 2017-00690), Swedish Research Council for Environmental, Agricultural Sciences and Spatial Planning, FORMAS (Grant No: 2018-00693), NanoLund, and The Swedish Research Council, VR (Grant No 2021-03265). The main funding body of The Swedish CArdioPulmonary bioImage Study (SCAPIS) is the Swedish Heart-Lung Foundation. The study is also funded by the Knut and Alice Wallenberg Foundation, the Swedish Research Council and VINNOVA (Sweden’s Innovation agency) the University of Gothenburg and Sahlgrenska University Hospital, Karolinska Institutet and Stockholm County council, Linköping University and University Hospital, Lund University and Skåne University Hospital, Umeå University and University Hospital, Uppsala University and University Hospital.