Age-related increase of monoamine oxidase B in amyloid-negative cognitively unimpaired elderly subjects

Abstract

Objective: Monoamine oxidase B (MAO-B) is highly abundant in reactive astrocytes and upregulated in neuroinflammatory processes. However, the age-related change of MAO-B in amyloid-negative cognitively unimpaired elderly subjects has not yet been sufficiently evaluated on positron emission tomography (PET). ¹⁸F-THK5351 is a radiotracer with high affinity to MAO-B, which may potentially serve as an imaging biomarker for detecting neuroinflammation. The purpose of this study was to investigate the age-related topographic change of ¹⁸F-THK5351 PET in amyloid-negative cognitively unimpaired elderly subjects.

Methods: The age-related change of ¹⁸F-THK5351 retention was evaluated on the visual analysis, voxel and region of interest (ROI)-based analyses using Statistical Parametric Mapping and PETSurfer tool of FreeSurfer in 31 amyloid-negative cognitively unimpaired elderly subjects.

Results: On visual inspection, elderly groups showed the spread of ¹⁸F-THK5351 accumulation from the medial to inferolateral temporal and basal frontal lobes, and cingulate gyrus. Additionally, voxel- and ROI-based analysis demonstrated the correlation between ¹⁸F-THK5351 accumulation and participants' age, especially in the inferior temporal lobes.

Conclusions: This study demonstrated age-dependent increase of ¹⁸F-THK5351 retention in amyloid-negative cognitively unimpaired subjects, which suggests an increase in MAO-B positive reactive astrocytes with aging.

Keywords: 18F-THK5351; Aging; Amyloid-negativity; Positron emission tomography.