CircRNAs in lung cancer- role and clinical application

Jingwei Li; Qiran Zhang; Decheng Jiang; Jun Shao; Weimin Li; Chengdi Wang

doi:10.1016/j.canlet.2022.215810

CircRNAs in lung cancer- role and clinical application

Cancer Lett. 2022 Sep 28:544:215810. doi: 10.1016/j.canlet.2022.215810. Epub 2022 Jun 30.

Authors

Jingwei Li¹, Qiran Zhang¹, Decheng Jiang², Jun Shao¹, Weimin Li³, Chengdi Wang⁴

Affiliations

¹ Department of Respiratory and Critical Care Medicine, Med-X Center for Manufacturing, Frontiers Science Center for Disease-related Molecular Network, West China Medical School/West China Hospital, Sichuan University, Chengdu, China.
² West China Medical School/West China Hospital, Sichuan University, Chengdu, China.
³ Department of Respiratory and Critical Care Medicine, Med-X Center for Manufacturing, Frontiers Science Center for Disease-related Molecular Network, West China Medical School/West China Hospital, Sichuan University, Chengdu, China. Electronic address: weimi003@scu.edu.cn.
⁴ Department of Respiratory and Critical Care Medicine, Med-X Center for Manufacturing, Frontiers Science Center for Disease-related Molecular Network, West China Medical School/West China Hospital, Sichuan University, Chengdu, China. Electronic address: chengdi_wang@scu.edu.cn.

PMID: 35780929
DOI: 10.1016/j.canlet.2022.215810

Abstract

Lung cancer holds the highest mortality rate among malignancies worldwide. Nevertheless, the potential molecular mechanisms of its tumorigenesis and evolution remain obscure. Circular RNAs (circRNAs), a broad category of covalently closed molecules, follow a malignancy-restricted expression pattern. Leading-edge studies have demonstrated the clinical application prospects of circRNAs in lung cancer. Herein, this review elucidates the biogenesis, biological functions, and pathophysiology of circRNAs. Furthermore, we underscore the forefront of the diagnostic, prognostic, and therapeutic potential of circRNAs in lung cancer as well as discuss the bottleneck that needs to be overcome to translate the basic advances of circRNAs into clinical practice.

Keywords: Biomarker; Circular RNAs; Pathophysiology; miRNA sponge.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carcinogenesis / pathology
Humans
Lung Neoplasms* / genetics
Lung Neoplasms* / pathology
Prognosis
RNA / genetics
RNA / metabolism
RNA, Circular* / genetics

Substances

RNA, Circular
RNA