Metastatic spread inhibition of cancer cells through stimuli-sensitive HPMA copolymer-bound actinonin nanomedicines

Nanomedicine. 2022 Aug:44:102578. doi: 10.1016/j.nano.2022.102578. Epub 2022 Jun 29.

Authors

Jana Kousalová¹, Milada Šírová², Libor Kostka¹, Vladimír Šubr¹, Jiřina Kovářová², Kateřina Běhalová², Martin Studenovský¹, Marek Kovář², Tomáš Etrych³

Affiliations

¹ Institute of Macromolecular Chemistry of the Czech Academy of Sciences, v.v.i., Heyrovského sq. 2, 16206 Prague, Czech Republic.
² Institute of Microbiology of the Czech Academy of Sciences, v.v.i., Vídeňská 1083, 14220 Prague, Czech Republic.
³ Institute of Macromolecular Chemistry of the Czech Academy of Sciences, v.v.i., Heyrovského sq. 2, 16206 Prague, Czech Republic. Electronic address: etrych@imc.cas.cz.

PMID: 35779856
DOI: 10.1016/j.nano.2022.102578

No abstract available

Keywords: Actinonin; Matrix metalloproteinases; Metastases; Polymer conjugate; pH-sensitive release.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Doxorubicin / pharmacology
Humans
Hydroxamic Acids
Methacrylates
Nanomedicine*
Neoplasms* / drug therapy
Polymers / pharmacology

Substances

Hydroxamic Acids
Methacrylates
Polymers
Doxorubicin
actinonin
hydroxypropyl methacrylate