Association of Vitamin B Status with Risk of Dementia in Cohort Studies: A Systematic Review and Meta-Analysis

Abstract

Objective: To examine the association between B vitamins status and the risk of dementia in older adults through a systematic review and meta-analysis of cohort studies.

Design: Systematic review and meta-analysis.

Setting and participants: Older adults aged ≥60 years from community, nursing home, institution, or hospital.

Methods: PubMed, Cochrane Library, EMBASE, Web of Science, CINAHL, ClinicalTrials, WHO-ICTRP, NHS Trusts, and ACTR were searched from the date of their inception up to November 28, 2021. We included cohort studies that assessed the association between serum B vitamins or B vitamins intake and the risk of dementia among older adults aged ≥60 years. The quality of all studies was assessed by the modified Newcastle-Ottawa Scale (NOS). The hazard ratios (HRs) and 95% CIs were calculated by the random effects model. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach was used to rate the certainty of evidence.

Results: Eleven cohort studies with sample sizes ranging from 233 to 3634 were included in the meta-analysis. Levels of serum folate showed statistically significant association with the risk of dementia (≥10 nmol/L: HR 1.57, 95% CI 1.01-2.46, low certainty; <10 nmol/L: HR 0.93, 95% CI 0.88-0.99, very low certainty). However, levels of vitamin B₆ intake showed no statistically significant effects on risk of dementia; levels of serum vitamin B₁₂ and vitamin B₁₂ intake also showed no statistically significant effects on risk of dementia in older adults.

Conclusions and implications: The results from our meta-analysis suggest that vitamin B₆, B₁₂, and folate may not be modifiable risk factors for dementia among older adults. Current evidence on the relationship between vitamin B status and dementia is not sufficient for development of vitamin B recommendations. More high-quality cohort studies are needed to confirm the relationship between the two in the future.

Keywords: Dementia; folate; risk factors; vitamin B(12); vitamin B(6).