Maternal calcium intake during pregnancy and childhood blood pressure: the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake; Keiko Tanaka; Hitomi Okubo; Satoshi Sasaki; Masashi Arakawa

doi:10.1016/j.annepidem.2022.06.035

Maternal calcium intake during pregnancy and childhood blood pressure: the Kyushu Okinawa Maternal and Child Health Study

Ann Epidemiol. 2022 Sep:73:17-21. doi: 10.1016/j.annepidem.2022.06.035. Epub 2022 Jun 29.

Authors

Yoshihiro Miyake¹, Keiko Tanaka², Hitomi Okubo³, Satoshi Sasaki⁴, Masashi Arakawa⁵

Affiliations

¹ Department of Epidemiology and Public Health, Ehime University Graduate School of Medicine, Ehime, Japan; Integrated Medical and Agricultural School of Public Health, Ehime University, Ehime, Japan; Research Promotion Unit, Translation Research Center, Ehime University Hospital, Ehime, Japan; Center for Data Science, Ehime University, Ehime, Japan. Electronic address: miyake.yoshihiro.ls@ehime-u.ac.jp.
² Department of Epidemiology and Public Health, Ehime University Graduate School of Medicine, Ehime, Japan; Integrated Medical and Agricultural School of Public Health, Ehime University, Ehime, Japan; Research Promotion Unit, Translation Research Center, Ehime University Hospital, Ehime, Japan; Center for Data Science, Ehime University, Ehime, Japan.
³ Department of Epidemiology and Public Health, Ehime University Graduate School of Medicine, Ehime, Japan; Department of Health Promotion, National Institute of Public Health, Saitama, Japan.
⁴ Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan.
⁵ Wellness Research Fields, Faculty of Global and Regional Studies, University of the Ryukyus, Okinawa, Japan; The Department of Cross Cultural Studies, Osaka University of Tourism, Okinawa, Japan.

PMID: 35777629
DOI: 10.1016/j.annepidem.2022.06.035

Abstract

Purpose: Evidence regarding the relationship between maternal calcium intake during pregnancy and childhood blood pressure is limited and inconsistent. The present prebirth cohort study examined this issue in Japanese children aged 6 years.

Methods: Subjects were 854 mother-child pairs. Maternal intake during pregnancy was assessed with a validated diet history questionnaire. A research technician measured systolic and diastolic blood pressures at home in children aged 6 years using an electronic sphygmomanometer. Analysis of covariance was used to calculate adjusted means of systolic and diastolic blood pressures according to maternal calcium intake during pregnancy.

Results: Maternal calcium intake during pregnancy was not related to systolic blood pressure in children. On the other hand, compared with children of mothers whose calcium intake during pregnancy was in the lowest quartile, those of mothers whose calcium intake during pregnancy was in the highest quartile had 2.8 mmHg lower adjusted mean diastolic blood pressure (95% confidence interval: 0.3-5.3 mmHg, P for trend = .009).

Conclusions: Higher maternal calcium intake during pregnancy may be associated with a decrease in diastolic, but not systolic, blood pressure in Japanese children aged 6 years.

Keywords: Blood pressure; Calcium; Japanese; Maternal intake; Prebirth cohort; Pregnancy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Blood Pressure
Calcium*
Child
Child Health
Cohort Studies
Female
Humans
Prenatal Exposure Delayed Effects*
Prospective Studies

Substances

Calcium