The risk of relapse in breast cancer patients is associated with MMP-9 gene polymorphism: a prospective study in a sample of the Iranian population

Nucleosides Nucleotides Nucleic Acids. 2022;41(10):1012-1023. doi: 10.1080/15257770.2022.2094946. Epub 2022 Jul 1.

Abstract

We investigated the association of MMP-9 rs1056628 and rs17576 polymorphisms with breast cancer (BC) relapse in a cohort of prospectively observed BC patients. The polymorphisms were genotyped in 200 BC subjects with(case) and without(control) relapse by Tetra-primer Amplification Refractory Mutation System-Polymerase Chain Reaction (T-ARMS-PCR) method. A significant association was found between the rs1056628C allele and increased risk of BC relapse (OR = 1.8, P = 0.006). Also, rs17576 allele and genotypes were shown protective effects against BC relapse. Increased risk of relapse was observed in haplotype CG (OR = 2.1, P = 0.001). Our results suggest for the first time that rs1056628 and rs17576 polymorphisms may influence BC relapse.

Keywords: Matrix metalloproteinase; breast cancer; haplotype; polymorphism; relapse.

MeSH terms

  • Breast Neoplasms* / genetics
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Iran / epidemiology
  • Matrix Metalloproteinase 9 / genetics
  • Neoplasm Recurrence, Local / genetics
  • Polymorphism, Single Nucleotide
  • Prospective Studies

Substances

  • Matrix Metalloproteinase 9