Targeting Eosinophils in Mouse Models of Asthma

Hope E Guthier; Nives Zimmermann

doi:10.1007/978-1-0716-2364-0_15

Targeting Eosinophils in Mouse Models of Asthma

Methods Mol Biol. 2022:2506:211-222. doi: 10.1007/978-1-0716-2364-0_15.

Authors

Hope E Guthier^{1

2}, Nives Zimmermann^{3

4

5}

Affiliations

¹ Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
² Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
³ Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA. nives.zimmermann@UC.edu.
⁴ Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA. nives.zimmermann@UC.edu.
⁵ Division of Allergy and Immunology, Department of Pediatrics (Cincinnati Children's Hospital), University of Cincinnati College of Medicine, Cincinnati, OH, USA. nives.zimmermann@UC.edu.

PMID: 35771474
DOI: 10.1007/978-1-0716-2364-0_15

Abstract

Eosinophils are bone marrow-derived hematopoietic cells that accumulate significantly in the lungs and bronchoalveolar lavage fluid in patients with asthma and models of allergic airway inflammation. Their role in the pathophysiology of asthma and other diseases can be studied using mouse models in which eosinophils are depleted. This review article focuses on two main approaches for depleting eosinophils in vivo, antibody-mediated and genetic models. Specific antibodies and genetic models are reviewed, along with their strengths and weaknesses.

Keywords: Allergic airway inflammation; Antibody-mediated depletion; Asthma; Eosinophil; Genetic models; Mouse models.

Publication types

Review

MeSH terms

Animals
Asthma*
Bronchoalveolar Lavage Fluid
Disease Models, Animal
Eosinophils*
Inflammation
Leukocyte Count
Lung
Mice