Chemerin Levels in Acute Coronary Syndrome: Systematic Review and Meta-Analysis

Abstract

Objective: We evaluated the relevant published studies exploring the association between chemerin concentrations and acute coronary syndromes (ACSs).

Methods: A systematic search was performed in October 2021 using PubMed, Scopus, Embase, and Cochrane Library. We included full articles and assessed their quality using the Newcastle-Ottawa score.

Results: We found 6 studies in the systematic review and 5 of these were included in our meta-analysis. Mean difference (MD) of 41.69 ng/mL (95% CI, 10.07-73.30), 132.14 ng/mL (95% CI, -102.12-366.40), and 62.10 ng/mL (95% CI, 10.31-113.89) in chemerin levels was seen in ACS patients vs control subjects, ACS patients vs stable angina pectoris patients (SAP), and type 2 diabetes mellitus (T2DM) ACS patients vs nondiabetic ACS patients, respectively.

Conclusion: Chemerin levels were significantly elevated in patients with ACS compared to controls, as well as in T2DM-ACS patients compared to nondiabetic ACS patients. However, no significant MD in chemerin levels was observed between SAP and ACS patients.

Keywords: acute coronary syndrome; chemerin; coronary artery disease; diabetes mellitus; ischemic heart disease; stable angina pectoris.