Determination of total purine and free purine content in milk, soymilk, and enteral nutritional supplements to assist nutritional therapy for hyperuricemia and gout

Nucleosides Nucleotides Nucleic Acids. 2022;41(12):1287-1295. doi: 10.1080/15257770.2022.2093362. Epub 2022 Jun 29.

Abstract

In this study, we determined the purine contents in milk and soymilk, as protein-rich drinks, and in enteral nutritional supplements employed to ameliorate protein malnutrition in the elderly. Milk consumption is known to lower serum uric acid levels and to promote uric acid excretion. However, discrepant results have been reported regarding the effect of soymilk on serum uric acid levels. The purpose of this study was to quantify and compare the total purine contents and the contents of individual purines and pyrimidines by molecular type (nucleotides, nucleosides, and bases).

Keywords: Determination of purine; enteral nutritional supplements; milk; purine contents; soy milk.

MeSH terms

  • Aged
  • Animals
  • Gout*
  • Humans
  • Hyperuricemia* / therapy
  • Milk / chemistry
  • Purines / metabolism
  • Uric Acid

Substances

  • purine
  • Uric Acid
  • Purines