Aging and macrophages: Not standing the test of time?

Suhas Sureshchandra; Ilhem Messaoudi

doi:10.1002/JLB.3CE0322-145R

Aging and macrophages: Not standing the test of time?

J Leukoc Biol. 2022 Dec;112(6):1369-1370. doi: 10.1002/JLB.3CE0322-145R. Epub 2022 Jun 29.

Authors

Suhas Sureshchandra^{1

2}, Ilhem Messaoudi³

Affiliations

¹ Institute for Immunology, University of California, Irvine, California, USA.
² Department of Physiology and Biophysics, University of California, Irvine, California, USA.
³ Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.

Abstract

The underlying mechanism of immunosenescence and compromised responses to environmental stressors in alveolar macrophages is a result of epigenetic dysregulation, rather than loss of subtypes.

Publication types

Editorial
Comment

MeSH terms

Immunosenescence* / physiology
Macrophages

Grants and funding

R01 AA028735/AA/NIAAA NIH HHS/United States