Autonomic Dysfunction in the Setting of CADASIL Syndrome

Ricci Allen; Nathan Kostick; Alan Tseng; Igor Sirotkin; Esther Baldinger

doi:10.12788/fp.0249

Autonomic Dysfunction in the Setting of CADASIL Syndrome

Fed Pract. 2022 Apr;39(Suppl 1):S21-S25. doi: 10.12788/fp.0249. Epub 2022 Apr 12.

Authors

Ricci Allen¹, Nathan Kostick¹, Alan Tseng^{2

3}, Igor Sirotkin², Esther Baldinger²

Affiliations

¹ University of Central Florida, College of Medicine, Orlando.
² Bay Pines Veterans Affairs Department of Neurology, Bay Pines, Florida.
³ Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Clearwater, Florida.

Abstract

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) syndrome is the most common monogenic inherited cause of stroke.

Case presentation: A female patient aged > 50 years with genetically proven CADASIL syndrome and an extensive stroke/transient ischemic attack (TIA) history experienced a bradycardic episode following hospitalization for new strokelike symptoms. The literature of cardiac involvement in CADASIL syndrome is limited, with no definitive recommendations for surveillance and screening.

Conclusions: This case report postulates that cardiac surveillance and screening may be indicated for patients with CADASIL syndrome.