Characterization of Extended-Spectrum β-Lactamase-Producing Shigella sonnei in Spain: Expanding the Geographic Distribution of Sequence Type 152/CTX-M-27 Clone

Antimicrob Agents Chemother. 2022 Jul 19;66(7):e0033422. doi: 10.1128/aac.00334-22. Epub 2022 Jun 28.

Abstract

We describe the first occurrence in Spain of community cases of CTX-M-27-producing Shigella sonnei sequence type 152 (ST152), resistant to quinolones and azithromycin. The cases included adult males and also one pediatric case. The isolates were clustered together with an Australian isolate and differed from other outbreak-causing strains in England by more than 50 alleles. They carried the blaCTX-M-27 gene on an 83-Kb F2:A-:B- plasmid, similar to that found in a British isolate.

Keywords: CTX-M-27; ESBL; ST152; Shigella sonnei; Spain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology
  • Australia
  • Child
  • Clone Cells
  • Dysentery, Bacillary* / drug therapy
  • Dysentery, Bacillary* / epidemiology
  • Humans
  • Male
  • Plasmids / genetics
  • Shigella sonnei* / genetics
  • Spain / epidemiology
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • beta-Lactamases