Structural characterization and anti-photoaging activity of a polysaccharide from Sargassum fusiforme

Jinhong Hu; Wanzi Yao; Shiyuan Chang; Lijun You; Mouming Zhao; Peter Chi-Keung Cheung; Kseniya Hileuskaya

doi:10.1016/j.foodres.2022.111267

Structural characterization and anti-photoaging activity of a polysaccharide from Sargassum fusiforme

Food Res Int. 2022 Jul:157:111267. doi: 10.1016/j.foodres.2022.111267. Epub 2022 Apr 20.

Authors

Jinhong Hu¹, Wanzi Yao¹, Shiyuan Chang¹, Lijun You², Mouming Zhao¹, Peter Chi-Keung Cheung³, Kseniya Hileuskaya⁴

Affiliations

¹ School of Food Science and Engineering, South China University of Technology, Guangzhou, Guangdong 510640, People's Republic of China; Research Institute for Food Nutrition and Human Health (111 Center), Guangzhou, Guangdong 510640, People's Republic of China.
² School of Food Science and Engineering, South China University of Technology, Guangzhou, Guangdong 510640, People's Republic of China; Research Institute for Food Nutrition and Human Health (111 Center), Guangzhou, Guangdong 510640, People's Republic of China. Electronic address: feyoulijun@scut.edu.cn.
³ Food & Nutritional Sciences Program, School of Life Sciences, Chinese University of Hong Kong, Hong Kong 999077, People's Republic of China.
⁴ Institute of Chemistry of New Materials, National Academy of Sciences of Belarus, Skaryna str., Minsk 220141, Belarus.

PMID: 35761578
DOI: 10.1016/j.foodres.2022.111267

Abstract

In this study, a purified algal polysaccharide (P1) was isolated from Sargassum fusiforme and its structural characteristics and anti-photoaging activity were studied. Results showed that P1 had a molecular weight of 289 kDa and was mainly composed of mannuronic acid, guluronic acid and fucose with molar ratio of 7.67:2.35:1.00. The backbone of P1 was →4)-β-ManA-(1→4)-α-GulA-(1→4)-β-ManA-(1→4)-β-ManA-(1→4)-α-GulA-(1→4)-β-ManA-(1→3,4)-β-ManA-(1→ with a terminal group of α-Fucp-(1→ linked to O-3 position of →3,4)-β-ManA-(1→. In addition, P1 could inhibit the expressions of MMPs (MMP-1, MMP-3 and MMP-9) in the UVB-irradiated HaCaT cells, indicating that P1 could reduce collagen loss caused by UVB irradiation. It also reduced the contents of ROS and inflammatory factors (TNF-α, IL-6 and IL-1β), indicating that P1 could reduce the oxidative stress and inflammation response. Thus, Sargassum fusiforme polysaccharide P1 could be used as a potential functional food to relieve skin photoaging.

Keywords: Algal polysaccharide; Anti-photoaging; Sargassum fusiforme; Structural characteristics; UVB irradiation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dietary Carbohydrates
Molecular Weight
Polysaccharides / chemistry
Sargassum* / chemistry
Ultraviolet Rays

Substances

Dietary Carbohydrates
Polysaccharides