An Overview of Alphafold's Breakthrough

Ştefan-Bogdan Marcu; Sabin Tăbîrcă; Mark Tangney

doi:10.3389/frai.2022.875587

An Overview of Alphafold's Breakthrough

Front Artif Intell. 2022 Jun 9:5:875587. doi: 10.3389/frai.2022.875587. eCollection 2022.

Authors

Ştefan-Bogdan Marcu¹, Sabin Tăbîrcă^{1

2}, Mark Tangney¹

Affiliations

¹ Department of Computer Science, University College Cork, Cork, Ireland.
² Department of Informatics, Faculty of Informatics and Mathematics, Transilvania University, Brasov, Romania.

Abstract

This paper presents a short summary of the protein folding problem, what it is and why it is significant. Introduces the CASP competition and how accuracy is measured. Looks at different approaches for solving the problem followed by a review of the current breakthroughs in the field introduced by AlphaFold 1 and AlphaFold 2.

Keywords: AI; AlphaFold; AlphaFold2; CASP; deep learning; neural networks; protein folding; transformers.

Publication types

Review