Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review

Minmin Chen; Mengyuan Liu; Chenyan Li; Shiqiao Peng; Yiling Li; Xiuying Xu; Mingjun Sun; Xuren Sun

doi:10.3389/fonc.2022.913217

Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review

Front Oncol. 2022 Jun 10:12:913217. doi: 10.3389/fonc.2022.913217. eCollection 2022.

Authors

Minmin Chen¹, Mengyuan Liu², Chenyan Li³, Shiqiao Peng³, Yiling Li¹, Xiuying Xu¹, Mingjun Sun^{1

2}, Xuren Sun¹

Affiliations

¹ Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, China.
² Department of Gastrointestinal Endoscopy, First Affiliated Hospital of China Medical University, Shenyang, China.
³ Department of Endocrinology and Metabolism, First Hospital of China Medical University, Shenyang, China.

Abstract

Immune checkpoint inhibitors (ICIs) have opened up a new way for tumor therapy but simultaneously led to the occurrence of immune-related adverse events. We report a case of successful treatment of PD-1 inhibitor-associated colitis with fecal microbiota transplantation (FMT). The patient was a palatal malignant melanoma who developed diarrhea and hematochezia accompanied by fever, gastrointestinal bleeding, and infection after the third treatment with PD-1 (Toripalimab). The patient received general treatment unsuccessful, corticosteroid therapy after initial success but rapid loss of response, and finally successful treatment after fecal microbiota transplantation.

Keywords: case report; colitis; fecal microbiota transplantation; immune checkpoint inhibitors; immunotherapy.

Publication types

Review