Eosinophilic Granulomatosis with Polyangiitis

Int J Appl Basic Med Res. 2022 Apr-Jun;12(2):148-150. doi: 10.4103/ijabmr.ijabmr_528_21. Epub 2022 May 10.

Abstract

Eosinophilic granulomatosis with polyangiitis also known as Churg-Strauss syndrome or allergic granulomatosis and angiitis is an extremely rare systemic necrotizing vasculitis that affects small-to-medium-sized vessels. Here, we report a case of a 58-year-old man presenting with painful swelling of bilateral lower limbs with multiple well-defined erosions on lower legs and dorsum of the foot with a few of them showing brownish crusts and with slight watery discharge and a few with raw areas. The patient is a known case of bronchial asthma. Histopathology of foot and face lesion shows inflammatory cell infiltrate predominantly comprising of eosinophils, small- and medium-sized blood vessels are thickened. P-antineutrophil cytoplasmic antibody positivity was seen. Thus, on the basis of positive findings which satisfy the criteria for eosinophilic granulomatosis with polyangiitis, we diagnosed this as a case of eosinophilic granulomatosis with polyangiitis, and for rarity of this case, we would like to report it.

Keywords: Churg–Strauss syndrome; P-antineutrophil cytoplasmic antibody; eosinophilia; eosinophilic granulomatosis with polyangiitis.

Publication types

  • Case Reports