Nonredundant Rac-GEF control of actin cytoskeleton reorganization

Marcelo G Kazanietz; Mariana Cooke; Rafael Garcia-Mata

doi:10.1016/j.tcb.2022.06.003

Nonredundant Rac-GEF control of actin cytoskeleton reorganization

Trends Cell Biol. 2022 Oct;32(10):815-818. doi: 10.1016/j.tcb.2022.06.003. Epub 2022 Jun 23.

Authors

Marcelo G Kazanietz¹, Mariana Cooke², Rafael Garcia-Mata³

Affiliations

¹ Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: marcelog@pennmedicine.upenn.edu.
² Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Einstein Medical Center Philadelphia, Philadelphia, PA 19141, USA.
³ Department of Biological Sciences, University of Toledo, Toledo, OH 43606, USA. Electronic address: rafael.garciamata@utoledo.edu.

Abstract

Rac-GEFs operate in a nonredundant manner as downstream effectors of receptor tyrosine kinases to promote ruffle formation, indicative of unique modes of regulation and targeting. Current research is shedding light on the intricate signaling paradigms shaping spatiotemporal activation of the small GTPase Rac during the generation of actin-rich membrane protrusions.

Keywords: Rac; Rac-GEFs; actin cytoskeleton; cancer; ruffles; small GTPases.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Actin Cytoskeleton / metabolism
Actins* / metabolism
Humans
Signal Transduction*

Substances

Actins

Abstract

Publication types

MeSH terms

Substances

Grants and funding